Scientist, Biopharmaceutics

Job Title: Scientist, Biopharmaceutics

Location: Cambridge, MA

About The Job

Are you ready to shape the future of medicine? The race is on to speed up drug discovery and development to find answers for patients and their families. Your skills could be critical in helping our teams accelerate progress.

The Drug Product Design (DPD)department provides the CMC expertise to advance projects through the lifecycle of development. As part of the Global CMC Development organization, DPD is striving to become an industry leader in the development of transformative medicines with scientific excellence and agility. The scope encompasses formulation for preclinical investigation, biopharmaceutics assessments for oral absorption of small molecules, and risk assessment for translational stage to clinical studies.

We are seeking a highly motivated and detail-oriented entry-level scientist to join our Biopharmaceutics team at Sanofi. In this role, you will have the opportunity to work on exciting and challenging projects involving the use of in vitro experiments to optimize simulations and inform drug product development decisions. You will collaborate with cross-functional teams to develop and implement novel computational methods and tools to accelerate the discovery and development of new drugs.

We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish and grow your career, with countless opportunities to explore, make connections with people, and stretch the limits of what you thought was possible. Ready to get started?

Main Responsibilities

• Conduct lab experiments to characterize the solubility and dissolution characteristics of the drug substance and drug product
• Develop and validate experimental methods to feed into simulation models to predict drug-excipient interactions and optimize formulation designs
• Develop and advance concepts of translational biopharmaceutics with a focus on improving predictive capabilities by linking in vitro drug product performance attributes to in vivo performance attributes.
• Assist in combining leading-edge in vitro and in silico capabilities with drug product design
• Design in vitro experiments to evaluate drug products using principles of quality by design and understanding of drug product manufacturing processes.
• Work in close collaboration with various groups to address the biopharmaceutical needs of oral, parenteral, transdermal, and other delivery routes.
  
  

Autonomy

• Work closely with global Teams in CMC organizations involved with selection of API final form, design of dosage forms and development of manufacturing processes of drug products.
• Demonstrated abilities to work in cross-disciplinary teams and ability to partner with cross-disciplinary subject matter experts in Pharmaceutical Sciences, Pharmacokinetics & Drug Metabolism, and Clinical Pharmacology departments.
  
  

About You

• Entry-level PhD, MS (3 years) in a formulation, biopharmaceutics, or a related field
• Experience with formulation, solubility, and dissolution experiments in biorelevant media
• Testing of prototype formulations to optimize absorption
• Expert knowledge in physiology and in pharmacokinetics
• Experience with running HPLC and/or UPLC
• Knowledge about solid state characterization
• Appropriate modeling and computer software experience in computer programs or PK software, i.e., Matlab, R, Python, WinNonlin, NONMEM, Gastroplus, Simcyp or similar programs.
• Excellent written and verbal communication skills
• Ability to work independently and collaboratively as part of a multidisciplinary team
  
  

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.
  
  

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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