Senior Scientist/Scientist
Sci.bio Recruiting
Date: 2 days ago
City: West Haven, CT
Contract type: Full time
Play an integral role in advancing our early therapeutic candidates into the clinic by employing state-of-the-art immuno-oncology and cancer
biology techniques to experimental animal models. Candidate will design and execute animal models as well as supervise outsourced specialized
animal model designs.
Responsibilities
biology techniques to experimental animal models. Candidate will design and execute animal models as well as supervise outsourced specialized
animal model designs.
Responsibilities
- Design and implement in vivo syngeneic or xenograft mouse models as appropriate. Experience with animal handling, cell and drug injections (IV, IP and SQ), human PBMC reconstitution in mice, and tumor volume measurements are required.
- Design and perform in vitro and ex vivo immunology-focused assays to assess the functional activity of candidate immuno-oncology therapeutics. Ex vivo FACS based assays of TIL infiltration required.
- Interrogate the function of myeloid cell populations in vivo, particularly in the context of the tumor microenvironment.
- Routinely used techniques include isolation of cells from primary human or mouse samples, leukocyte immunophenotyping by multi-parameter flow cytometry, designing functional immune cell-based assays evaluating various aspects of immune cell behavior (phagocytosis, ADCC, ADCP, cytokine production), as well as transcriptional or signaling changes
- Organizing and analyzing results, troubleshooting assays/models, communicating and presenting findings in team meetings, and contributing to scientific publications
- Troubleshooting and optimizing results through surveying the literature, data interpretation, identification of novel or alternative procedures and techniques, and timely execution of experiments
- PhD degree in Immunology, Cancer Biology, or a related field, with 5+ years of relevant experience in an industrial or academic lab setting.
- Deep knowledge of immuno-oncology and tumor biology animal models
- Ability to design, develop, and execute research activities in a timely manner.
- Strong communication skills, and proven ability to collaborate in a team setting.
- Ability to multi-task in a fast-paced, dynamic environment while delivering high quality work.
- Experience with cell culture and animal model techniques, including cell line growth and specimen isolation from mouse tissue samples.
- Experience with immunological techniques (e.g., ELISA, flow cytometry) and with immune cell based functional assays
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