Temp Sr. Scientist, Formulation and Delivery Sciences

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

TEMP SENIOR SCIENTIST, FORMULATION AND DELIVERY SCIENCES

SUMMARY:

We seek inquisitive and motivated RAs/scientists to help build an exciting new gene editing franchise within a leading nucleic acid therapeutics company. This is an onsite laboratory-based role in preclinical formulations R&D for the intracellular delivery of RNA. The successful candidate will create novel nanoparticles comprising nucleic acids, lipids, polymers and peptides, perform physical-chemical characterizations, and conduct in-vivo / in-vitro studies.

RESPONSIBILITIES:

• Contribute to the design, production, and testing of a variety of nucleic acid containing nanoparticles for preclinical research programs and transition to clinical development.
• Produce bench scale formulations using microfluidic mixing and UF/DF, filtration, centrifugation, etc.
• Perform routine rodent procedures to dose formulations and assess safety/activity.
• Perform routine particle analysis via DLS, zeta potential, TNS pKa, fluorescence methods, and potentially analyze lipids and RNAs via HPLC, etc.
• Proactively collaborate with scientists across the organization to advance company objectives
• Thoroughly document results in electronic lab notebooks and present findings to cross-functional teams
• Assist in maintaining general laboratory functionality including ordering and receiving lab supplies
• Analyze experimental data and present scientific results at team research meetings
• Contribute to publications and patent applications
  
  

REQUIREMENTS:

• BS in life sciences, pharmaceutical sciences, chemical engineering, bioengineering, or related discipline with at least 5 years of relevant experience for Senior RA role
• MS in life sciences, pharmaceutical sciences, chemical engineering, bioengineering, or related discipline with at least 3 years of relevant experience for Senior RA role
• PhD in life sciences, pharmaceutical sciences, engineering or related discipline for a Scientist role.
• Specific level will be based on each candidate’s combination of skills and accomplishments.
• Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy) is required. Experience with cell culture is a plus.
• Experience formulating and characterizing RNA and/or protein containing nanoparticles
• Experience with analytical methods for RNA and/or lipids is a strong plus
• A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment
• Ability to engage experts and literature to troubleshoot complex scientific problems.
• Excellent organizational and written/verbal communication skills
  
  

REQUIREMENTS:

For more information about Ionis and to apply for this position, please visit our website, http://www.ionis.com. Reference Requisition #TEMP003499

The hourly pay scale for this position is $52.92/hour to $67.67/hour

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.