Principal Scientist, Translational Research at GondolaBio

Company Background

GondolaBio is a collection of biopharmaceutical companies focused on developing next-generation therapeutics for genetic diseases. Originally carved out of BridgeBio, GondolaBio secured $300M in private financing from external investors in 2024 and became an independent company within the BridgeBio ecosystem. GondolaBio aims to leverage cutting-edge biological research to discover, create, test, and deliver transformative medicines to treat patients who suffer from genetic diseases.

Portal Therapeutics is an early clinical stage biotechnology company, and the lead program in GondolaBio’s portfolio. Portal is developing a novel potential best-in-class therapy for erythropoietic protoporphyria, a severe genetic disease of the blood which results in extreme sensitivity to sunlight and liver damage.

Who You Are:

We seek an entrepreneurial scientist to drive the biology and translational research for Portal Therapeutics. You will be supporting strategy and direction, assay development, mouse model experimentation, preclinical dose guidance, regulatory document writing including INDs, and other translational biology and pharmacology experiments through a combination of internal and external efforts. This job requires excellent communication and interpersonal skills as well as technical and scientific abilities. We hope to hear from you.

Requirements and Responsibilities:

• Support critical translational studies that further elucidate the mechanism, biology, and understanding of the Portal drug
• Support biology, pharmacology, and translational research for Portal
• Understanding of the biology and pharmacology of the relevant disease area and treatment approaches
• Manage relationships with CROs for efficient execution of all the preclinical and translational studies
• Collaborate with cross-functional teams, including DMPK, toxicology, clinical development, regulatory to advance our therapeutic candidates through clinical development in a fast-paced, dynamic environment
• Represent the program scientifically to internal and external audiences
• Contribute to due diligence and gap analysis on potential new GondolaBio assets

Education, Experience & Skills Requirements:

• Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or related discipline with 6+ years of industry experience in bioanalytical sciences; or M.S. with 10+ years.
• Strong scientific background and achievements in bioscience and translational, ideally demonstrated by scientific publications, presentations, and/or patents
• Proven track record of successfully working in research programs and teams
• Strong understanding of drug discovery and development processes
• Excellent communication, leadership, and organizational skills
• Ability to think strategically and execute effectively
• Experience in collaborating with cross-functional teams and external partners
• Knowledge of regulatory requirements and industry standards
• Demonstrate creative 'out of the box' thinking to solve complex technical problems and champion innovative technologies to achieve project goals
• Commitment, drive, and ownership mindset

What We Offer:

• Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
• A culture inspired by our values: put patients first; think independently; be radically transparent; every minute counts; and let the science speak
• Collaborative business environment
• Excellent compensation package (Base, Performance Bonus, Equity)
• Excellent benefits package
• Flexible PTO
• A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• A platform for meaningful scientific contributions to shine

Salary:

The base pay range for this position is $185,000 to $210,000 per year. The actual compensation offered will be determined based on a number of job-related factors, including experience, skills, qualifications, and location. A bonus plan and equity will also be offered.