Biologist at Synectics Inc.

Description

• The Quantitative, Translational ADME Sciences (QTAS) department at is seeking a highly motivated and energetic bioanalytical scientist to join the biologics bioanalysis, characterization and proteomics (BBCP) group.
• The primary responsibility of this position is to support LC-MS (liquid chromatography-mass spectrometry)-based bioanalysis and method development for biologic entities, such as monoclonal antibodies, multi-specific antibodies, antibody-drug conjugates (ADCs), and other novel modalities.
• The successful candidate will have experience in optimizing and implementing hybrid LC-MS-based bioanalytical methods to support non-regulated preclinical PK and TK studies.
• Responsibilities include routine sample preparation, method development, instrument maintenance, data analysis, report writing, and presenting data at internal and external meetings.
• Perform affinity purification and digestion of biological therapeutics (including but not limited to monoclonal and bispecific antibodies, antibody drug conjugates, antibody-siRNA conjugates, and fusion proteins) from biological matrices manually or using automation systems.
• Operate and maintain LC/MS instruments to generate high-quality experimental data.
• Optimize and develop LC/MS methods to meet assay specificity and sensitivity requirements.
• Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks.
• Communicate data interpretation internally and externally.
  
  

Qualifications

• BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on mass spectrometry.
• Degree in chemistry, pharmacology or other related fields.
• Prior industry experience in drug discovery/development is highly desired.
• Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor.
• Hands-on experience with QQQ (SCIEX) is required, additional experience with qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers is a plus.
• Hands-on experience with biologics bioanalysis is highly desired, additional experience with oligonucleotide analysis is a plus.
• Hands-on experience with immuno-affinity purification and automation systems (e.g., TECAN, AssayMap Bravo or Hamilton) is highly desired.
• In-depth understanding of PK, TK and PK/PD studies is preferred.
  
  

Benefits

Healthcare Insurance: Synectics offers eligible employees and their dependents healthcare coverage through BlueCross BlueShield of Illinois. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics. Premiums are subsidized by Synectics.

Dental Insurance: Synectics offers eligible employees and their dependents a dental plan through MetLife. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.

Vision Insurance: Synectics offers eligible employees vision insurance through VSP. Eligibility begins on the 1st day of the calendar month following 60 days of continuous full time employment with Synectics.401(k) Plan: The Synectics Inc. Investment Savings Retirement Plan. Synectics offers all employees who are 21 years of age or older the opportunity to invest in the 401(k) Plan on the first enrollment date that is at least 30 days after employment begins. Enrollment dates are each January 1st, April 1st, July 1st, and October 1st.

Technical Certification Bonus: Synectics is pleased to award its employees a bonus of up to $500 for an approved professional certification. In determining the bonus amount, Synectics will consider the cost of the test(s) for any certification relating to your current position, achieved during your employment with us. Only one Certification Bonus per calendar year may be awarded per employee. Only current, active employees will be eligible to receive this bonus. It will be awarded 90 days after the Synectics office has received documentation confirming the successful completion of the certification.

Synectics is an equal opportunity employer.