Research Assistant - #9824092

Job Description: The Research Assistant will assist with conducting experiments to examine the cellular processes by which specific genetic variants modify neurodevelopmental phenotypes associated with Autism spectrum disorders. The Research Assistant will use genetic, cell biological, stem cell, epigenetic, genome editing, and molecular techniques to elucidate the molecular mechanisms underlying the role of the chromatin environment on human neuronal development. The Research Assistant will assist with carrying out specific experiments that involve maintenance of stem cells, neuronal differentiation of human stem cells, immunohistochemistry, imaging, molecular techniques and biochemical assays. In addition, the Research Assistant will also assist senior researchers with data analyses. The Research Assistant will also engage in and assist with general lab support duties
Using a combination of genome edited and patient derived induced pluripotent stem cells (iPSCs) the laboratory of Dr. Sofia Lizarraga hopes to gain a better understanding of the underlying mechanisms that could eventually lead to the development of much needed therapeutics for difficult to treat autism. They focus on chromatin regulatory mechanisms associated with disruption of histone methyl transferase function and their effect in neuronal structure and function in stem cell derived neurons
This is a fixed term position with a current end date of one year from the date of hire which may be extended based upon available funding Job Qualifications
Education and Experience: Grade 7:

• Required: Bachelor degree. Relevant coursework and knowledge of laboratory approaches and techniques in the areas of Developmental Biology, Stem cell Biology, Cellular neuroscience, Molecular, and Biochemistry
• Preferred: Bachelor degree in biology, genetics, neuroscience, or biochemistry
• Or, equivalent combination of education and experience
• Strong computer skills with preferably some experience using graphing, image and statistical analysis programs is preferred
• Experience using human stem cells to model neuronal differentiations is preferred
• Experience using CRISPR genome editing techniques is preferred

Grade 8:

• Required: Bachelor degree in biology, genetics, neuroscience, biochemistry, or related field and 1-2 years’ research experience in a laboratory setting
• Relevant coursework and knowledge of laboratory approaches and techniques in the areas of Developmental Biology, Stem cell Biology, Cellular neuroscience, Molecular, and Biochemistry is preferred
• Or, equivalent combination of education and experience
• Strong computer skills with preferably some experience using graphing, image and statistical analysis programs including R is preferred
• Experience using human stem cells to model neuronal development is preferred
• Experience conducting CRISPR/CAS genome editing is preferred
• Experience working with human stem cells and neuronal differentiation of human stem cells is preferred
• Tissue culture experience is required
• Cloning expertise is required

Job Competencies:

• Conceptually comfortable with genetic and molecular genetic approaches
• Attention to detail, outstanding hand/eye coordination, consistent execution of multi-step protocols
• Ability to learn new skills quickly
• Excellent organizational and record-keeping skills
• Excellent written and communication skills
• Ability to be observant and self-motivated
• Ability to think critically and problem-solve
• Ability to complete accurate records and follow detailed instructions
• Ability to work as part of a team, strong interpersonal skills
• Ability to communicate clearly and professionally with co-workers
• Working knowledge of Microsoft Office software suite and competence in statistical analysis using Graph Pad software is desired
• Working knowledge of R or Python is desired
• Possesses a willingness and ability to support a diverse and inclusive campus community

CRIMINAL BACKGROUND AND EDUCATION CHECK REQUIRED Recruiting Start Date: 2024-04-10 Job Posting Title: Research Assistant Department: Department of Molecular Biology, Cell Biology and Biochemistry Grade: Grade 7 Worker Type: Employee Worker Sub-Type: Fixed Term (Fixed Term) Time Type: Full time Scheduled Weekly Hours: 37.5 Position Work Location: Onsite Submission Guidelines: Please note that in order to be considered an applicant for any staff position at Brown University you must submit an application form for each position for which you believe you are qualified. Applications are not kept on file for future positions. Please include a cover letter and resume with each position application Still Have Questions? If you have any questions you may contact [email protected] EEO Statement: Brown University is an E-Verify Employer As an EEO/AA employer , Brown University provides equal opportunity and prohibits discrimination, harassment and retaliation based upon a person’s race, color, religion, sex, age, national or ethnic origin, disability, veteran status, sexual orientation, gender identity, gender expression, or any other characteristic protected under applicable law, and caste, which is protected by our University policies.