Research Scientist / Senior Research Scientist, Chemical Biology & Proteomics

We are seeking a highly motivated and dedicated scientist to join our Chemical Biology & Proteomics (CBP) team at AstraZeneca in Waltham, MA. As a Research Scientist / Senior Research Scientist, you will be an integral member of a team generating pre-clinical pharmacology data to understand efficacy and selectivity of therapeutics agents. You will have the opportunity to work with a team of cross functional scientists and support the development of new and successful therapies for patients. If you’re inspired by the possibilities of science to make a difference and ready to discover what you can do – join us.

Key Responsibilities

• Develop and employ chemical tools and proteomics technologies to provide impactful mechanistic insights for drug discovery projects across therapeutic areas
• Design and complete experimental plans to understand target engagement and selectivity profiles of therapeutic agents
• Develop mass spectrometry-based methods to understand drug-induced proteome dynamics and investigate post-translational modifications (PTM)
• Represent CBP team, and communicate with project subject area leads, and contribute to generation of mechanistic hypothesis through interpretation of sophisticated proteomics data
• Maintain and troubleshoot LC-MS system

Essential Requirements

• M.S. in Analytical Chemistry, Biochemistry or a related field (RS), or PhD with 2+ years of post-doctoral/industrial experience (SRS)
• Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/or absolute protein quantification)
• Proven expertise with IP-MS or chemical probe-based enrichment MS workflows, and experience developing automated processes to analyze large number of samples for MS analysis
• Skilled in investigating compound effect under biochemical and cellular settings by quantitative mass spectrometry, e.g. PTMs, protein complexes perturbations, etc
• Experience in determining protein abundance and turnover by using quantitative proteomics technologies, such as TMT, SILAC, and/or label-free approaches and data independent acquisition (DIA)
• Expertise in data analysis and an ability to communicate data interpretation clearly
• Significant external reputation gained through professional recognition, external presentation and publication in high-impact journals
• Ability to contribute with a positive, result oriented and problem-solving attitude

Desirable Requirements

• Experience in pre-clinical drug discovery
• Experience using Thermo Q-Exactive, Orbitrap Fusion Lumos, Exploris, Eclipse, or TimsTOF
• Experience with Xcalibur, Proteome Discoverer, MaxQuant, Skyline, Spectronaut and DB search engine tools
• Experience with liquid handling systems and robotic automation
• Familiarity with targeted proteomics is a plus

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and ignite your entrepreneurial spirit. There is no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

Next Steps – Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a phenomenal fit, please share this posting with them.