Research Scientist

About Duke University School of Medicine

Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing and Duke University Health System comprise Duke Health, a world-class academic medical center.

The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.

Research Focus

The Zhou lab focuses on the elucidation of the structure and dynamics of protein–protein and protein–ligand interactions and their functions in various cellular processes. Current efforts are directed at enzymes and protein complexes involved in bacterial membrane biosynthesis, translesion DNA synthesis, co-transcriptional regulation, and host-pathogen interactions. Investigations of these cellular machineries have led to the development of novel antibiotics and cancer therapeutics, as well as the establishment of new biotechnology initiatives.

Position Overview

The new research scientist is expected to be integrated with research activities in areas such as bacterial pathogenesis, lipid A biosynthesis in Gram-negative bacteria, and development of antibiotics and cancer therapeutics, assisting Dr. Zhou with lab management.

Minimum Requirements:

This position requires a minimum of six years of postdoctoral experience in scientific research, with a strong record of publications and contributions to the field. The candidate will conduct independent research and assist with laboratory management.

Preferred Qualifications:

The ideal candidate will have:

• A demonstrated track record of publications in lipid A enzymology and inhibition.
• Expertise in in vivo studies using murine infection and tumor models.
• Proficiency in lipid biochemistry, purification, enzymology, bacterial genetics, and genome engineering.
• Experience with whole genome sequencing analysis and bioinformatics focused on bacterial genomes.

Prior industrial experience is desirable. Strong communication skills are essential for collaboration in multidisciplinary research.

Work Responsibilities:

Scientific Research

• Create analysis plans and perform analyses on research questions aimed at developing novel antibiotics and cancer therapeutics.
• Independently write and edit funding proposals, review articles, and develop manuscripts.
• Develop protocols or research proposals and contribute to peer-reviewed publications and conference presentations.
• Serve as an expert resource for data management and analysis.

Program Management and Project Development

• Contribute to the research program, leading in developing scientific content for proposals and manuscripts.
• Maintain communications to ensure successful research partnerships.

Leadership and Professionalism

• Stay current with research updates and oversee implementation in the research portfolio.
• Demonstrate leadership and facilitate change in the research program.

Choose Duke.

Join an award-winning team recognized by Forbes as America’s Best Large Employer 2024. Duke offers exciting opportunities and a competitive benefits package, including health insurance, generous paid time off, retirement programs, and tuition assistance.

Diversity Statements:

Duke is an Affirmative Action/Equal Opportunity Employer committed to diversity and inclusion. We strive for a community where all voices are heard and valued.