Research Associate, Chemical Development

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position: Nurix is seeking a dedicated and detail-oriented Research Assistant to join our Chemical Development team. The successful candidate will support the development and optimization of chemical processes for the synthesis of novel therapeutic compounds. This role requires a solid foundation in organic chemistry, excellent laboratory skills, and the ability to work collaboratively in a dynamic research environment.

Key Responsibilities

• Assist in the design and execution of characterization experiments (OVAT and/or DOE), including for the synthesis and optimization of manufacturing process
• Conduct process characterization studies for the manufacturing process
• Perform routine laboratory tasks, including preparation of reagents, purification of compounds, and maintenance of laboratory equipment.
• Conduct analytical testing using techniques such as HPLC, NMR, and mass spectrometry.
• Record and analyze experimental data, ensuring accuracy and reproducibility.
• Collaborate with team members to troubleshoot and resolve experimental challenges.
• Maintain a clean and organized laboratory workspace.
• Prepare technical reports and presentations to communicate laboratory findings.
• Work up to 80% of the time in the laboratory.
  
  
  

Qualifications

• High School or GED with experience in petroleum or chemical industry; preferably B.S. or M.S. in Chemistry, Chemical Engineering, or a related field.
• Hands-on experience in a laboratory setting, preferably in organic synthesis or chemical development.
• Familiarity with common analytical techniques (e.g., HPLC, NMR, mass spectrometry).
• Strong attention to detail and excellent organizational skills.
• Ability to work independently and as part of a team.
• Good written and verbal communication skills.
• Proficiency in data analysis and interpretation.
• Proficiency in the use of scientific databases such as Scifinder and Reaxys.
  
  
  

Bonus Qualifications

• Experience in the pharmaceutical industry.
• Hands-on experience of conducting processes on 5-20 L scale.
• Experience in setting up and maintaining 1-20 L jacketed reaction vessels
• Experience in the use of Dynochem for process modeling.
• Experience in the use of Design of Experiment software such as JMP and Design Expert
  
  
  

Nurix provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age or genetics. In addition to federal law requirements, Nurix complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfers, leaves of absence, compensation, and training. Nurix expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic, information, disability, or veteran status. Improper interference with the ability of Nurix’s employees to perform their job duties may result in discipline up to and including discharge.

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